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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
ARHGEF11
All Species:
13.64
Human Site:
Y539
Identified Species:
33.33
UniProt:
O15085
Number Species:
9
Phosphosite Substitution
Charge Score:
0
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
O15085
NP_055599.1
1522
167704
Y539
K
R
N
P
I
L
K
Y
I
G
K
P
K
S
S
Chimpanzee
Pan troglodytes
XP_001167782
1522
167643
Y539
K
R
N
P
I
L
K
Y
I
G
K
P
K
S
S
Rhesus Macaque
Macaca mulatta
XP_001116835
1522
167570
Y539
K
R
N
P
I
L
K
Y
I
G
K
P
K
S
S
Dog
Lupus familis
XP_547523
1545
170397
Y581
R
R
N
P
I
L
K
Y
I
G
K
P
K
S
S
Cat
Felis silvestris
Mouse
Mus musculus
Q8R4H2
1543
172304
I600
K
R
R
G
F
P
S
I
L
G
P
P
R
R
P
Rat
Rattus norvegicus
Q9ES67
1527
168515
P553
L
E
D
K
K
R
N
P
I
L
R
Y
I
G
K
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001505606
1628
182548
I655
K
R
R
G
F
P
N
I
L
G
P
P
R
R
P
Chicken
Gallus gallus
XP_423659
1337
148636
P439
G
S
D
T
P
F
T
P
T
T
E
Q
G
S
E
Frog
Xenopus laevis
NP_001082763
1450
164220
V547
M
K
H
L
G
V
K
V
K
E
P
R
S
L
E
Zebra Danio
Brachydanio rerio
NP_001027010
1417
157480
G507
R
D
S
K
V
F
P
G
L
M
S
E
K
E
K
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
Sea Urchin
Strong. purpuratus
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
99.5
97.7
84.9
N.A.
30.9
83.6
N.A.
30.8
62.5
31.6
43.8
N.A.
N.A.
N.A.
N.A.
N.A.
Protein Similarity:
100
99.6
98.4
89.3
N.A.
49
89.4
N.A.
46.8
69.7
50
59.3
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Identity:
100
100
100
93.3
N.A.
26.6
6.6
N.A.
26.6
6.6
6.6
6.6
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Similarity:
100
100
100
100
N.A.
40
20
N.A.
40
20
26.6
33.3
N.A.
N.A.
N.A.
N.A.
N.A.
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% A
% Cys:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% C
% Asp:
0
10
20
0
0
0
0
0
0
0
0
0
0
0
0
% D
% Glu:
0
10
0
0
0
0
0
0
0
10
10
10
0
10
20
% E
% Phe:
0
0
0
0
20
20
0
0
0
0
0
0
0
0
0
% F
% Gly:
10
0
0
20
10
0
0
10
0
60
0
0
10
10
0
% G
% His:
0
0
10
0
0
0
0
0
0
0
0
0
0
0
0
% H
% Ile:
0
0
0
0
40
0
0
20
50
0
0
0
10
0
0
% I
% Lys:
50
10
0
20
10
0
50
0
10
0
40
0
50
0
20
% K
% Leu:
10
0
0
10
0
40
0
0
30
10
0
0
0
10
0
% L
% Met:
10
0
0
0
0
0
0
0
0
10
0
0
0
0
0
% M
% Asn:
0
0
40
0
0
0
20
0
0
0
0
0
0
0
0
% N
% Pro:
0
0
0
40
10
20
10
20
0
0
30
60
0
0
20
% P
% Gln:
0
0
0
0
0
0
0
0
0
0
0
10
0
0
0
% Q
% Arg:
20
60
20
0
0
10
0
0
0
0
10
10
20
20
0
% R
% Ser:
0
10
10
0
0
0
10
0
0
0
10
0
10
50
40
% S
% Thr:
0
0
0
10
0
0
10
0
10
10
0
0
0
0
0
% T
% Val:
0
0
0
0
10
10
0
10
0
0
0
0
0
0
0
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
0
0
0
0
0
40
0
0
0
10
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _